Allylic Functionalization of Unactivated Olefins with Grignard Reagents
نویسندگان
چکیده
منابع مشابه
Highly enantioselective Cu-catalysed allylic substitutions with Grignard reagents.
A catalyst system able to perform highly enantioselective Cu-catalysed allylic alkylations with Grignard reagents is described.
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A solution to the classic unsolved problem of olefin hydromethylation is presented. This highly chemoselective method can tolerate labile and reactive chemical functionalities and uses a simple set of reagents. An array of olefins, including mono-, di-, and trisubstituted olefins, are all smoothly hydromethylated. This mild protocol can be used to simplify the synthesis of a specific target or ...
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A copper-free allylic arylation reaction between 3,3-disubstituted allylic halides and triazene-softened aryl Grignard reagents has been developed. This protocol presents a direct and efficient way to construct both α- or γ-isomers with high regioselectivity under environmentally benign conditions. Various functional groups can be tolerated in the reaction and the products are of high value for...
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ژورنال
عنوان ژورنال: Angewandte Chemie International Edition
سال: 2014
ISSN: 1433-7851
DOI: 10.1002/anie.201309134